Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

This study tests whether spironolactone — a medication that blocks male hormones — can normalize the way the brain releases a reproductive hormone (LH) during sleep in teenage girls who have high androgen (male hormone) levels. This hormonal imbalance is often an early sign of polycystic ovary syndrome (PCOS). **You may be eligible if:** - You are a girl between 10 and 17 years old in mid to late puberty - You have elevated levels of testosterone or signs of excess hair growth (hirsutism) - You are otherwise in good health - You are willing to use non-hormonal contraception during the study **You may NOT be eligible if:** - You are male - You are younger than 10 or older than 17 - You have been through menopause for more than 4 years - You are pregnant or breastfeeding - You weigh less than 21.5 kg - You have diabetes, significant liver or kidney problems, high potassium, adrenal disease, or a history of cancer - You have signs of another cause for high androgen levels (not PCOS-related) Talk to your doctor to see if this trial is right for you.