Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy

This study tests whether high-intensity interval training (HIIT) exercise during chemotherapy helps prevent the thinking and memory problems ("chemo brain") that some breast cancer patients experience. It uses brain scans to measure any changes in brain function. **You may be eligible if:** - You are a woman 18 or older newly diagnosed with stage I–III breast cancer - You are scheduled to receive chemotherapy before or after surgery - You currently exercise less than 60 minutes per week - You speak English and do not smoke - You are able to get clearance from your doctor to exercise **You may NOT be eligible if:** - You have metastatic (stage IV) breast cancer or another active cancer - You have uncontrolled diabetes, hypertension, or thyroid disease - You have heart disease, heart failure, or a pacemaker - You are pregnant or have claustrophobia - You already exercise more than 60 minutes per week in a structured program - You are unable to travel to the Dana-Farber Cancer Institute Talk to your doctor to see if this trial is right for you.