Study of Parameters of Osteosarcopenia in Patients With Hip Fracture
Study of Parameters of Bone Fragility and Sarcopenia in Patients Undergoing Surgery for Fracture of the Femoral Neck
Istituto Ortopedico Rizzoli
100 participants
Nov 23, 2020
OBSERVATIONAL
Conditions
Summary
The study aims to assess the adequacy of a set of clinical and laboratory investigations for identifying the osteosarcopenia status in patients undergoing a hip replacement for a fragility fracture of the femoral neck. The control group will consist of patients undergoing a hip replacement for osteoarthritis, as the decrease in muscle function and bone quality is less severe in this condition than in osteoporosis.
Eligibility
Plain Language Summary
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Interventions
Assessment of muscle performance based on self-reported information about grip strength, assistance with walking, rising from a chair, climbing stairs, and falls.
Assessment of histomorphology and matrix-structure of tissue samples obtained from the bone resected during the hip prosthesis positioning.
Assessment of histomorphology and ultrastructure of muscle biopsies taken from the upper portion of the vastus lateralis muscle, which is accessed in the surgical procedure of hip replacement.
Quantification of circulating myostatin, a muscle-specific biomarker that suppresses muscle growth and bone formation.
Quantification of circulating IGF-1, a growth factor that promotes muscle growth and osteogenesis.
Assessment of dietary habits based on self-reported information about the monthly- weekly- or daily-frequency consumption of main food groups, including cereals and bread, meat, fish, fruit, vegetable, legumes, dairy products, sweets and snacks, drinks, and dietary supplements.
Assessment of gut microbiome composition on stool samples.
Locations(1)
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NCT04730622