RecruitingNot ApplicableNCT04731246

Video-oculography and Parkinson's Disease

Video-oculography and Parkinson's Disease: A Prospective Study


Sponsor

Association de Recherche Bibliographique pour les Neurosciences

Enrollment

30 participants

Start Date

Jul 7, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to study, in patient with Parkinson's disease, mild to moderate stage (according to Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, Postuma et al., 2015): * the evolution of oculomotricity markers over time. * the correlation between neurological evaluations (motor and non-motor scores), neuropsychological evaluations (cognitive disorders) and oculomotricity evaluation, over a follow-up period of 7 years. * the impact of antiparkinsonian drugs on the evolution of oculomotricity assessment by video-oculography. * the value of oculomotricity assessment by video-oculography as an evolutionary marker of the disease.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses eye-tracking technology (video-oculography) to explore eye movement abnormalities in patients with Parkinson's disease. Eye movements are controlled by brain regions affected by Parkinson's, and measuring them precisely may help improve diagnosis and track disease progression. **You may be eligible if:** - You have a confirmed diagnosis of idiopathic (typical) Parkinson's disease - Your Parkinson's is in an early to moderate stage (Hoehn and Yahr score 1–3) - You have had a brain MRI and a dopamine scan (DaTSCAN or F-DOPA PET) confirming the diagnosis - Your cognitive function is normal or only mildly impaired - You speak French sufficiently - You have a caregiver **You may NOT be eligible if:** - You have a psychiatric condition other than mild anxiety or depression - You have significant neurological comorbidities - Your brain MRI shows significant vascular disease or another brain condition - Your symptoms suggest a different type of Parkinsonism (not typical Parkinson's disease) - You have major cognitive impairment or dementia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERVideo-oculography / Neuropsychological evaluations

Annual evaluation: Medical history; Clinical, Neurological and Neuropsychological evaluations; Video-oculography examination; Inventory of examinations carried out in routine care (brain MRI, cerebral DaTScan, cerebral F-Dopa PET/CT scan, MIBG myocardial scintigraphy, blood test). Follow-up is carried out over 7 years.


Locations(1)

Centre Mémoire / Centre de Gérontologie Clinique Rainier III / Princess Grace Hospital

Monaco, Monaco

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NCT04731246


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