RecruitingNot ApplicableNCT04743271

Food and Circadian Timing

Uncovering the Impact of Diet on the Human Circadian Timing System


Sponsor

Oregon Health and Science University

Enrollment

14 participants

Start Date

Apr 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.


Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria1

  • Healthy, lean men and women

Exclusion Criteria27

  • Major dietary restrictions (such as entirely dairy-free and/or meat-free diets)
  • A body mass index (BMI) of 18.5< \[BMI\] < 24.9 kg/m\^2 and a waist circumference <94/80cm
  • Currently psychiatrically/psychologically unsuitable for participation
  • Drug/alcohol use, including smoking
  • Medication/drug use, including prescribed and over-the-counter medications
  • History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.
  • Traveled across more than 1 time zone during the 3 months prior to the study
  • Currently consuming a habitual high-fat diet
  • Chronobiologic and sleep disorders
  • Diseases of the Cardiovascular System
  • Metabolic Syndrome; Two or more of these factors will be excluded from the study:
  • HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women;
  • systolic blood pressure>135 mmHg or diastolic blood pressure>85 mmHg;
  • Fasting blood glucose ≥ 100 mg/dL;
  • Triglycerides ≥ 150 mg/dL.
  • Pre-Diabetes/Diabetes
  • Hypertension
  • Disorders of the Respiratory System
  • Disorders of the Kidney and Urinary Tract
  • Infectious Diseases
  • Disorders of the Gastrointestinal System
  • Disorders of the Immune System
  • Disorders of the Hematopoietic System
  • Neoplastic Diseases
  • Endocrine and Metabolic Diseases
  • Neurologic Disorders
  • Subjects must not be currently participating in another research study that would influence their safe participation in our study

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Interventions

OTHERHigh-Fat Diet

The diet will consist of a breakfast, lunch, dinner, and snack

OTHERLow-Fat Diet

The diet will consist of a breakfast, lunch, dinner, and snack


Locations(1)

Oregon Health & Science University

Portland, Oregon, United States

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NCT04743271


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