Coronary Computed Tomographic Angiography in Intermediate-risk Chest Pain Patients
Randomized Evaluation of Coronary Computed Tomographic Angiography in Intermediate-risk Patients Presenting to the Emergency Department With Chest Pain
Karolinska Institutet
1,600 participants
Jan 21, 2021
INTERVENTIONAL
Conditions
Summary
The aim is to determine whether a diagnostic strategy including early coronary computed tomographic angiography in intermediate-risk patients presenting to the Emergency Department with chest pain reduces the composite endpoint of death, readmission because of myocardial infarction or unstable angina requiring revascularization.
Eligibility
Inclusion Criteria4
- Age≥18 years.
- Within 24 hours from presenting to the ED with chest pain or other symptoms suggestive of coronary artery disease (CAD)
- HEART-score >3 (according to http://www.heartscore.nl/)
- Written informed consent obtained
Exclusion Criteria11
- Any condition that may influence the patient's ability to comply with study protocol.
- Acute MI
- Known obstructive CAD (>50%) or previous PCI or CABG.
- Clear alternative diagnosis
- Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m2
- Major allergy to iodinated contrast media
- Circumstances making high quality images unlikely.
- Not a Swedish resident with a personal ID-number.
- Pregnancy or breast feeding
- Further investigation for CAD not indicated, due to limited life expectancy, quality of life or functional status
- Previous inclusion in the trial
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Interventions
CCTA as soon as possible, preferably within 24 hours, but not later than within 21 days.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04748237