NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial

Inclusion Criteria16

• Informed consent before any study-related activities.
• Men or women \>18 years of age who are scheduled for non-emergent cardiac surgery procedures requiring CPB and are at increased risk for surgery-related adverse cardiovascular outcomes.
• Procedures include:
• CABG
• Aortic, mitral, tricuspid, or pulmonic valve replacement or repair
• CABG with aortic, mitral, tricuspid, and/or pulmonic valve replacement
• Risk factors for surgery related to adverse cardiovascular outcomes include one or more of the following:
• Valve surgery
• eGFR \< 45 ml/min/1.73m2
• Documented LVEF ≤ 35% within six months before surgery
• Documented history of heart failure
• Insulin-requiring diabetes
• Non-insulin-requiring diabetes and the presence of ≥+2 proteinuria on urinalysis (or equivalent on urine protein-to-creatinine ratio or urine albumin-to-creatinine ratio)
• Preoperative anemia (hemoglobin \<11g/dl for men and women)
• History of prior CABG
• Age ≥65