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RecruitingPhase 1Phase 2NCT04753970

Retina is a Marker for Cerebrovascular Heath

Retinal Vasoreactivity is a Marker for Cerebral Small Vessel Disease Progression

Sponsor

Mayo Clinic

Enrollment

100 participants

Start Date

Feb 9, 2021

Study Type

INTERVENTIONAL

Conditions

Cerebral Small Vessel DiseasesCerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and LeukoencephalopathyCerebral MicrobleedingSporadic White Matter Disease

Summary

Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression. This study aims to test whether impaired cerebral and retinal vasoreactivity may serve as biomarker for SVD progression, and to evaluate the safety and efficacy of cilostazol (antiplatelet agent with vasodilatory and anti-inflammatory properties) for the treatment of SVD.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Cilostazol for people with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, cerebral microbleeding, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCilostazol

Cilostazol 100mg BID

Locations(1)

Mayo Clinic Florida

Jacksonville, Florida, United States

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NCT04753970

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