Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes

This study uses advanced PET scans and tissue biopsies to understand how exercise affects insulin resistance and energy production in the muscles and fat of people with type 2 diabetes, with the goal of identifying better treatment targets. **You may be eligible if...** - You are between 30 and 65 years old - You have type 2 diabetes (by self-report or fasting blood sugar above 126 mg/dL) - Your BMI is between 25 and 45 - You exercise very little (1 day or less per week) - Your weight has been stable for the past 3 months **You may NOT be eligible if...** - You have type 1 diabetes or are on insulin - You have significant heart, kidney, or liver disease - You are pregnant or planning to become pregnant - You exercise regularly Talk to your doctor to see if this trial is right for you.