RecruitingNot ApplicableNCT04788524

Neural Correlates of Stress and Perceived Control in Adolescent Depression

Sponsor

Mclean Hospital

Enrollment

80 participants

Start Date

Apr 23, 2021

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder

Summary

Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Eligibility

Sex: FEMALEMin Age: 14 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is researching how stress and feelings of control affect the brains of teenage girls with depression. Researchers will use brain imaging and daily mood tracking to better understand why some teens develop depression and how the brain processes stress differently in depressed versus non-depressed adolescents. **You may be eligible if...** - You are a female between 14 and 18 years old - You are right-handed - English is your first language or you are fluent in English - You have a personal cell phone (for daily mood check-ins) - Your parent or guardian can provide consent if you are under 18 - You are in the follicular phase of your menstrual cycle at the time of study activities **You may NOT be eligible if...** - You are male - You are left-handed - You do not meet the age or language requirements - You are unable to participate in brain scanning procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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