Clinical Study of VG161 in Subjects with Advanced Primary Liver Cancer

This study is testing a new type of treatment called VG161 — an engineered virus that can both attack cancer cells directly and stimulate the immune system — in people with advanced liver cancer that has stopped responding to standard therapies. **You may be eligible if...** - You have advanced liver cancer (hepatocellular carcinoma, bile duct cancer, or combined type) - Your cancer is no longer responding to, or you cannot tolerate, standard treatments - You are in acceptable general health - You have measurable tumors that can be evaluated during the study **You may NOT be eligible if...** - You have severe liver failure or other organ failure - You are pregnant or breastfeeding - You have certain immune system conditions or are on immune-suppressing medications - You have uncontrolled infections Talk to your doctor to see if this trial is right for you.