RecruitingNot ApplicableNCT04806568

MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Sclerosis

Cognitive Decline Prognosis in Multiple Sclerosis: Effectiveness of a Computerized Cognitive Training Treatment on Cortical Reorganization

Sponsor

Aristotle University Of Thessaloniki

Enrollment

180 participants

Start Date

Dec 1, 2020

Study Type

INTERVENTIONAL

Conditions

Cognitive Decline Multiple Sclerosis

Summary

This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a structured cognitive training program (brain exercises) can create measurable changes in brain activity and structure in people with multiple sclerosis (MS) who experience thinking and memory problems, and whether it improves daily functioning. **You may be eligible if...** - You are between 18 and 65 years old - You have a confirmed diagnosis of multiple sclerosis (relapsing or progressive) - Your disability level is mild to moderate (EDSS score 0 to 6.5) - Your condition has been neurologically stable for at least 3 months **You may NOT be eligible if...** - You have severe physical or cognitive disability - You are currently experiencing a relapse - You have a major psychiatric condition - You are unable to participate in cognitive testing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCognitive Training

The cognitive training treatment is a Greek adaptation of BrainHQ developed by Posit Science Corporation. The intervention will target speed, attention, working memory, and executive function through the visual and auditory domains via a set of 15 exercises. Each daily training session consists of four exercises chosen from an active set of six. Participants will be instructed to train for one hour per day, three days per week, over 12 weeks via a tablet. Each subject will receive at least 29 sessions of computerized cognitive training.

DEVICEMonitoring of daily activity

Monitoring of daily activity via Fitbit Charge 4 smartwatch.

Locations(1)

Laboratory of Medical Physics and Digital Innovation, AUTH

Thessaloniki, Central Macedonia, Greece

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NCT04806568

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