RecruitingNot ApplicableNCT04807530

Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

Causal Role of Medial Prefrontal Neural Activity in Self-Agency in Schizophrenia


Sponsor

University of California, San Francisco

Enrollment

160 participants

Start Date

Nov 12, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increased mPFC excitability by active high-frequency nrTMS in HC and SZ will induce behavioral improvements in self-agency and neural changes in the larger self-agency network that will generalize to improvements in overall cognition, symptoms and daily functioning, and will likely lead to the development of new effective neuromodulation therapies in patients with schizophrenia.


Eligibility

Min Age: 18 YearsMax Age: 64 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced brain imaging to study the front part of the brain (medial prefrontal cortex) in people with schizophrenia during social and emotional tasks, to better understand how it functions differently and potentially identify targets for new treatments. **You may be eligible if...** - You are in good general physical health - English is your first language - You do not have a neurological disorder - You meet MRI safety requirements (no metal implants, etc.) - If you have schizophrenia: your diagnosis is confirmed, and you have been clinically stable for at least 12 weeks as an outpatient **You may NOT be eligible if...** - You have an active alcohol or substance use disorder - You have a neurological condition affecting the brain - You are not able to safely undergo MRI - You have unstable psychiatric symptoms Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETMS

The investigators will use the NEXSTIM NAVIGATED BRAIN STIMULATION (NBS) SYSTEM to apply 10 Hz nrTMS to healthy controls (HC) and schizophrenia patients (SZ)


Locations(1)

UCSF

San Francisco, California, United States

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NCT04807530


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