Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia

This trial is testing whether adding a medication called lumateperone (already used for schizophrenia) to clozapine treatment can reduce the serious metabolic side effects — like weight gain, high blood sugar, and abnormal cholesterol — that clozapine commonly causes in people with schizophrenia. **You may be eligible if...** - You have been diagnosed with schizophrenia or schizoaffective disorder - You have been taking clozapine for at least 6 months at a stable dose - You are psychiatrically stable and compliant with your medications - You are using appropriate birth control if you could become pregnant **You may NOT be eligible if...** - You are currently psychiatrically unstable - You have an active substance use disorder (other than caffeine or nicotine) - You have serious unstable medical conditions affecting your heart, liver, or kidneys - You have a history of seizures - You are pregnant or breastfeeding - You have taken lumateperone in the past 3 months Talk to your doctor to see if this trial is right for you.