Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy
Impact of Tranexamic Acid Use on Blood Loss and Transfusion Rates After Hip Reconstruction in Children, A Randomized Controlled Trial
Assiut University
400 participants
Apr 3, 2025
INTERVENTIONAL
Summary
Surgical hip reconstruction reduces the hip joint through soft tissue releases and osteotomies of the femur and/or pelvis. Blood loss and subsequent blood transfusion are normal consequences of hip reconstruction.
Eligibility
Inclusion Criteria2
- ASA I - II
- Scheduled for acetabular osteotomy and/or proximal femoral derotation osteotomies.
Exclusion Criteria5
- Patient's guardian refusal to participate in the study.
- Children known to have pre-existing bleeding or coagulation disorders.
- Children with anemia; defined according to (WHO ) cutoffs as Hb level<11g/dl for girls and <12g/dl for boys
- History of epilepsy.
- History of renal insufficiency or failure
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Interventions
patients treated with TXA will have reduced blood loss and transfusion requirements compared with those who did not receive TXA
regional anesthesia in orthopedic procedures are known to help reduction of intraoperative blood loss
participants will receive standard care but neither TXA nor caudal epidural block
Locations(1)
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NCT04811313