Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment
Neuromodulation Through Brain Stimulation-assisted Cognitive Training in Patients With Post-chemotherapy Cognitive Impairment
University Medicine Greifswald
52 participants
Nov 2, 2021
INTERVENTIONAL
Conditions
Summary
The aim of this study is to investigate whether a high definition tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast cancer treatment.
Eligibility
Inclusion Criteria4
- Chemotherapy to treat breast cancer (≥ 6 months post-treatment).
- Self-reported concerns regarding cognitive functioning.
- Age: 18-65 years.
- right-handedness
Exclusion Criteria6
- History of dementia before treatment of cancer.
- Other neurodegenerative neurological disorders; epilepsy or history of seizures.
- Severe and untreated medical conditions that preclude participation in the training, as determined by responsible physician.
- History of moderate to severe substance use disorder according to DSM-5
- Moderate to severe acute psychiatric disorders according to DSM-5
- Contraindication to tDCS application (Antal et al., 2017)
Interventions
Anodal transcranial direct current stimulation (tDCS), 9 sessions with 20 minutes stimulation each (2 mA).
Sham transcranial direct current stimulation (tDCS), 9 sessions with 30 sec stimulation each (2 mA) to ensure blinding of participants.
Intensive cognitive training of a letter memory updating task, 9 sessions for approximately 20 min
Locations(1)
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NCT04817566