RecruitingEarly Phase 1NCT04838678

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension


Sponsor

University of Texas Southwestern Medical Center

Enrollment

100 participants

Start Date

Jul 18, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the nervous system's automatic control of blood pressure (the sympathetic nervous system) differs between people who are a healthy weight, obese, or have high blood pressure — and how obesity may contribute to high blood pressure. **You may be eligible if you fall into one of the following groups:** - Healthy weight (BMI under 30), aged 18–55, without high blood pressure - High blood pressure diagnosis confirmed by a 24-hour blood pressure monitor, aged 18–55, BMI under 30 - Obese (BMI over 30), aged 18–55, without high blood pressure - Obese with high blood pressure (BMI over 30), aged 18–55 **You may NOT be eligible if:** - You have significant heart disease, kidney disease, diabetes, or a history of smoking Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNeuropeptide Y

intra-arterial infusion of neuropeptide Y


Locations(1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

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NCT04838678


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