RecruitingPhase 1Phase 2NCT04864054

T-Cell Therapy (ECT204) in Adults With Advanced HCC

An Open-Label, Dose Escalation, Multi-Center Phase I/II Clinical Trial of ECT204 T-Cell Therapy in Adults With Advanced Hepatocellular Carcinoma (HCC) (ARYA-3)


Sponsor

Eureka Therapeutics Inc.

Enrollment

20 participants

Start Date

Mar 11, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label, dose escalation, multi-center, Phase I/II clinical trial aimed at assessing the safety and preliminary efficacy of an investigational ARTEMIS® ECT204 T-cell therapy. The trial is suitable for adult subjects (≥ 18 years of age) diagnosed with GPC3-positive HCC, who have failed or not tolerated at least two (2) different anti-HCC systemic agents.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized T-cell therapy called ECT204 in adults with advanced liver cancer (hepatocellular carcinoma, or HCC). The therapy uses a patient's own immune cells, engineered to target a protein called GPC3 found on many liver cancer cells. **You may be eligible if...** - You have confirmed advanced, unresectable, or metastatic hepatocellular carcinoma - Your tumor tests positive for the GPC3 protein - You have already tried at least two different systemic treatments that either did not work or you could not tolerate - Your life expectancy is at least 4 months **You may NOT be eligible if...** - Your tumor does not express the GPC3 protein - You have not yet tried available standard treatments - Your general health is too poor for this type of therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALECT204 T cells

ECT204 is an autologous T-cell therapy whereby a subject's own T cells are transduced with a lentiviral vector expressing the ECT204 transgene.


Locations(7)

City of Hope

Duarte, California, United States

Kansas University Medical Center, Principal Investigator:

Westwood, Kansas, United States

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States

Oregon Health and Sciences University

Portland, Oregon, United States

University of Texas Southwestern, Harold C. Simmons Comprehensive Cancer Center

Dallas, Texas, United States

Fred Hutchinson Cancer Center, University of Washington

Seattle, Washington, United States

National Taiwan University Cancer Center

Taipei, Taiwan

View Full Details on ClinicalTrials.gov

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NCT04864054


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