Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery

This trial is comparing two chemotherapy approaches for patients with a type of bile duct cancer (intrahepatic cholangiocarcinoma) that has not spread beyond the liver but cannot be surgically removed. One group receives standard chemotherapy (gemcitabine + oxaliplatin); the other also receives a pump placed in a liver artery to deliver an additional drug (floxuridine) directly to the liver. **You may be eligible if...** - You are 18 or older with confirmed intrahepatic cholangiocarcinoma (a type of bile duct cancer) - Your cancer is confined to the liver (or nearby lymph nodes that can be removed) - Your cancer cannot be surgically removed at this time - You have measurable disease and adequate organ function - You are a candidate for general anesthesia and a surgical pump placement procedure **You may NOT be eligible if...** - Your cancer has spread outside the liver to distant organs - You have previously received chemotherapy for this cancer or prior liver radiation or ablation - You have portal hypertension (fluid in the abdomen or varicose veins in the esophagus) - You are pregnant or breastfeeding - You have peripheral neuropathy (nerve damage) or a life expectancy under 12 weeks Talk to your doctor to see if this trial is right for you.