Liver Transplantation in Intrahepatic Cholangiocarcinoma

This study is evaluating liver transplantation as a treatment option for people with intrahepatic cholangiocarcinoma (iCCA) — a type of bile duct cancer that starts inside the liver — that is locally advanced and cannot be surgically removed. Patients who have had stable disease on pre-transplant drug therapy may qualify for a transplant. **You may be eligible if...** - You are 18 or older - You have a confirmed diagnosis of locally advanced intrahepatic cholangiocarcinoma - Your cancer cannot be surgically removed due to its location or underlying liver disease - There is no spread to blood vessels, lymph nodes, or outside the liver - Your disease has been stable or improving for at least 6 months on drug therapy before transplant consideration **You may NOT be eligible if...** - Your cancer has spread to lymph nodes, blood vessels, or outside the liver - Your disease has not been stable for at least 6 months on neoadjuvant therapy - You have conditions that would make you ineligible for liver transplantation Talk to your doctor to see if this trial is right for you.