Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women
Julie Pendergast
164 participants
Oct 19, 2021
INTERVENTIONAL
Conditions
Summary
This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms and the associated metabolic dysfunction. It is hypothesized that time-restricted feeding will improve insulin sensitivity, glucose tolerance, body weight, and other metabolic parameters in metabolically-unhealthy postmenopausal women.
Eligibility
Inclusion Criteria3
- postmenopausal women
- age 45-65 years
- prediabetic or have at least 2 features of metabolic syndrome
Exclusion Criteria15
- on hormone therapy
- diabetes
- heart disease
- alcohol consumption of \>2 drinks per day
- significant circadian disruption
- having care-taking responsibilities that significantly affect sleep
- shift work or irregular lifestyle
- uncontrolled sleep apnea or other uncontrolled sleep disorder
- extreme early or late chronotypes
- significant psychiatric disorders
- taking ADHD medications
- diagnosed dysregulated eating behaviors
- smoking \>5 cigarettes/day or 30 pack-year history
- participating in formal weight loss program
- not weight stable
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Interventions
Subjects will be educated about the health benefits of time-restricted feeding (TRF). Each subject in the TRF group will self-select a 10 hour (10h +/- 1hr) window aligned with their active phase during which they will consume all daily calories. Subjects will text the time of their first and last daily meals for the duration of the study.
Locations(1)
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NCT04893226