Metabolic Syndrome Clinical Trials

176 recruitingLast updated: June 17, 2026

There are 176 actively recruiting metabolic syndrome clinical trials across 41 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1. Top locations include Beijing, Beijing Municipality, China, Singapore, Singapore, La Jolla, California, United States. Updated daily from ClinicalTrials.gov.


Metabolic Syndrome Trials at a Glance

176 actively recruiting trials for metabolic syndrome are listed on ClinicalTrialsFinder across 6 cities in 41 countries. The largest study group is Not Applicable with 94 trials, with the heaviest enrollment activity in Beijing, Singapore, and La Jolla. Lead sponsors running metabolic syndrome studies include Cairo University, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, and Ohio State University.

Browse metabolic syndrome trials by phase

Treatments under study

About Metabolic Syndrome Clinical Trials

Looking for clinical trials for Metabolic Syndrome? There are currently 161 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metabolic Syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metabolic Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 176 trials

Recruiting
Not Applicable

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Metabolic SyndromeDiabetes Mellitus, Type 2Prediabetes
Cleerly, Inc.7,500 enrolled124 locationsNCT06112418
Recruiting
Not Applicable

Our Voices Matter: Intervention for Depression in Youth

Metabolic SyndromeDepressive SymptomsAllostatic Load
Ann & Robert H Lurie Children's Hospital of Chicago300 enrolled1 locationNCT07216326
Recruiting

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

CancerInsulin ResistanceMetabolic Syndrome+2 more
National Institute of Environmental Health Sciences (NIEHS)725 enrolled1 locationNCT01143480
Recruiting
Not Applicable

Theory-based Health Behaviour Change Intervention in Individuals of Metabolic Syndrome With Chronic Kidney Disease

Metabolic SyndromeChronic Kidney Diseases
Chinese University of Hong Kong160 enrolled1 locationNCT06715735
Recruiting
Not Applicable

Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease

Metabolic SyndromeChronic Kidney Diseases
Chinese University of Hong Kong40 enrolled1 locationNCT06527768
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting
Not Applicable

Exercise Effects on Adipose Tissue Structure and Function

ObesityInsulin ResistanceWeight Loss+3 more
University of Michigan46 enrolled1 locationNCT04812314
Recruiting
Phase 2Phase 3

Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)

Metabolic SyndromeSpinal Cord InjuryTraumatic Spinal Cord Injury+1 more
Northwell Health60 enrolled3 locationsNCT07625332
Recruiting
Phase 2

Combined Oral Contraceptive Pill and Resistance Starch

Metabolic SyndromePolycystic Ovary Syndrome
University of Pennsylvania100 enrolled1 locationNCT06852365
Recruiting
Not Applicable

Impact of Yo-Yo Sleep on Cardiometabolic Health

ObesityCardiometabolic Syndrome
Columbia University72 enrolled1 locationNCT05880758
Recruiting
Not Applicable

The Mom and Infant Outcomes (MOMI) Study

Cardiometabolic SyndromePostpartum DepressionPostpartum Anxiety
Ohio State University384 enrolled1 locationNCT06277661
Recruiting
Not Applicable

Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs

Obesity and Metabolic Syndrome
Tri-Service General Hospital120 enrolled1 locationNCT07589322
Recruiting
Phase 1Phase 2

The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function

ObesityMetabolic Syndrome
Vanderbilt University Medical Center74 enrolled1 locationNCT05972564
Recruiting

Genetics of Obesity in Chinese Youngs

ObesityMetabolic Syndrome
Shanghai Jiao Tong University School of Medicine8,000 enrolled1 locationNCT01084967
Recruiting
Not Applicable

Animal and Plant Proteins and Glucose Metabolism

Metabolic SyndromeGlucose Metabolism DisordersMetabolic Syndrome, Protection Against
University of Missouri-Columbia100 enrolled1 locationNCT03994367
Recruiting
Not Applicable

Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly

Metabolic SyndromeType 2 Diabetes Mellitus (T2DM)Older Adults (65 Years and Older)+1 more
National Medical Research Center for Therapy and Preventive Medicine250 enrolled1 locationNCT07574333
Recruiting
Phase 4

Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome

Metabolic Syndrome
University of Virginia80 enrolled1 locationNCT04575844
Recruiting
Not Applicable

Low-Energy Shock Wave Therapy for Overactive Bladder in Women With Metabolic Syndrome

Metabolic SyndromeLower Urinary Track SymptomsBladder+2 more
KMUHIRB-F(I)-2023005160 enrolled1 locationNCT07563764
Recruiting

Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications

Metabolic SyndromeInflammationOverweight and Obesity
University of Rijeka200 enrolled1 locationNCT07431593