Preoperative, Proton- Radiotherapy Combined With Chemotherapy for Borderline Resectable Pancreatic Cancer

This trial is studying whether proton beam radiation combined with chemotherapy (nab-paclitaxel and gemcitabine) given before surgery can make borderline resectable pancreatic cancer operable — meaning cancer that is technically possible to remove but risky due to its location near major blood vessels. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of pancreatic cancer - Your tumor is classified as 'borderline resectable' (near blood vessels but not definitively unremovable) - There is no evidence of distant spread (no metastases) - You have adequate blood counts, liver function, and kidney function - Your performance status is good (Karnofsky index ≥70) - You have not had prior treatment for pancreatic cancer **You may NOT be eligible if...** - Your tumor is a non-exocrine type (like neuroendocrine) - Your cancer has spread to other parts of the body - You have already had abdominal radiation - You are allergic to paclitaxel, gemcitabine, or albumin - You have severe neuropathy (nerve damage) at baseline - You are pregnant or unwilling to use contraception Talk to your doctor to see if this trial is right for you.