RecruitingNot ApplicableNCT04898790

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation

Sponsor

University of Nebraska

Enrollment

88 participants

Start Date

Nov 18, 2021

Study Type

INTERVENTIONAL

Conditions

Multiple Myeloma Lymphoma Leukemia Myeloproliferative Neoplasm Myelodysplastic Syndromes (MDS)

Summary

Cancer and treatment-related cognitive changes, such as thinking or remembering, hinder resumption of normal routine and roles and worsen quality of life. Older adults undergoing hematopoietic cell transplantation (HCT) are at high-risk for cognitive impairment. Age is a risk factor for Alzheimer's Dementia (AD) and the hematological malignancies leading to HCT. There are shared mechanisms and interactions between AD and cancer-related cognitive decline (CRCD). Physical activity improves cognitive function in older adults and survivors of other cancers. This study hypothesizes that increasing physical activity can also improve cognitive function in this vulnerable population. The study has two goals. The first is to adapt and test an evidence-based physical activity intervention, The Community Health Activities Model Program for Seniors II (CHAMPS II), in the HCT setting for adults 55 years and older. This will be done using semi-structured interview of up to 10 patients who have experienced the HCT process within the last 3 to 6 months with HCT care-team partners. The second goal will explore the prevalence and impact of AD-neuropathology and inflammation on cancer-related cognitive decline (CRCD) in older adults undergoing HCT.

Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study explores ways to protect and improve thinking and memory in older adults who have had a stem cell transplant (a treatment for blood cancers). It also includes their caregivers and transplant care team members. **You may be eligible if...** - You are 55 years old or older (or 60+ for one part of the study) - You have a blood cancer such as leukemia, lymphoma, or myeloma - You have had or are planning to have a stem cell transplant - You are able to walk a short distance (about 13 feet), with or without assistance - You speak and read English - Caregivers and healthcare team members aged 19+ may also be eligible **You may NOT be eligible if...** - You had significant chest pain or severe shortness of breath during physical testing - Your doctor has not cleared you for light exercise - You have had a recent heart attack, uncontrolled irregular heartbeat, or very low heart pumping function - You have active moderate-to-severe psychiatric symptoms - You have had a major stroke with lasting effects Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCHAMPS-II adapted to adults 60+ years in HCT setting

CHAMPS-II is an evidence-based physical activity program designed to increase physical activity in sedentary older adults with multiple chronic health conditions. This is an individually tailored program that provides information, skills, training, and problem-solving support to older adults. Participants will engage in progressive, light to moderate-intensity physical activity throughout the HCT process, with the support of physical therapists, physical activity counselors, and their care-partner. They will take part in supervised exercise sessions; unsupervised exercise sessions; counseling sessions to address barriers, motivators, goals, and safety; and receive telephone support. Walking is the primary mode of aerobic activity, with training in flexibility, strengthening and balance exercises also included. An exercise kit will be provided, consisting of an intervention workbook, therapeutic resistance bands, and activity logs.

Locations(1)

University of Nebraska Medical Center

Omaha, Nebraska, United States

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