Hepatic Histopathology in Urea Cycle Disorders

This study collects and examines liver tissue from people with urea cycle disorders — rare genetic conditions where the liver cannot properly process nitrogen from protein, leading to toxic ammonia buildup. The researchers want to understand what liver damage looks like in these conditions and how it relates to disease severity. You may be eligible if: - You have been diagnosed with a primary urea cycle disorder confirmed by enzyme activity, DNA testing, or metabolite analysis - You have already had a liver transplant or liver biopsy, OR you are scheduled for one You may NOT be eligible if: - The liver tissue, biopsy report, or pathology slides are unavailable - You have a known secondary cause of liver disease (such as viral hepatitis, alcohol-related liver disease, autoimmune liver disease, or TPN-related cholestasis) Talk to your doctor to see if this trial is right for you.