RecruitingPhase 2NCT06488313

A Study to Evaluate the Pharmacodynamics and Safety of ARCT-810 in Participants With OTCD

A Phase 2a, Open-label, Multiple Ascending Dose Study to Evaluate the Pharmacodynamics and Safety of ARCT-810 in Adolescent and Adult Participants With Ornithine Transcarbamylase Deficiency

Sponsor

Arcturus Therapeutics, Inc.

Enrollment

9 participants

Start Date

Nov 4, 2024

Study Type

INTERVENTIONAL

Conditions

Ornithine Transcarbamylase Deficiency OTC Deficiency OTCD

Summary

Evaluate the safety and pharmacodynamics of multiple doses of ARCT-810 in adolescent and adult participants with OTC deficiency.

Eligibility

Min Age: 12 Years

Inclusion Criteria7

Willingness and ability to comply with all the protocol requirements, complete all study visits and sign informed consent.
Males and Females aged ≥12 years, at Screening.
Documented clinical diagnosis of OTC deficiency.
History of symptomatic hyperammonemia or elevated plasma ammonia or glutamine with clinical stability for at least 1 month prior to Screening.
Medically managed for OTC deficiency and receiving a stable protein-restricted diet, dietary supplements, and/or ammonia scavenger regimen (if applicable) for at least 28 days.
Good general health with no clinically significant abnormal findings that would interfere with study procedures (including plasma ammonia within participant's historical range).
Must be willing to adhere to contraception guidelines.

Exclusion Criteria20

Uncontrolled hypertension.
Symptoms of infection for at least 7 days prior to dosing.
Malignancy within 5 years, except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated.
History of any OTC gene therapy, or history of liver-derived stem cell therapy in the past 2 years.
History of any organ transplant.
History of severe allergic reaction to a liposomal or PEG-containing product.
History of congenital or acquired cardiac disorders.
Abuse of medications, illicit drugs or alcohol.
Blood donation of 50 to 499 mL within 30 days of screening or of \>499 mL within 60 days of screening.
Clinically significant laboratory abnormalities on screening labs including INR \>1.5, eGFR\< 60 mL/min/1.73m2 or positive test results for HIV, HBV, or HCV.
Inadequately controlled diabetes.
Clinically significant anemia.
Changes in maintenance therapies for OTC deficiency with 28 days prior to dosing.
Medical history requiring continuous or intermittent systemic corticosteroid administration.
Receipt of inhibitors of urea synthesis or drugs that significantly affect renal clearance.
Recent treatment with another investigational drug, biological agent, or device.
Treatment with any oligonucleotide (siRNA or mRNA) within 6 months prior to screening. COVID-19 vaccines are not exclusionary.
Involved in study conduct or an immediate family member of an individual involved in the study.
Participated in another dosing cohort of the study.
Any other conditions, in the opinion of the investigator, that would interfere with participation.

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Interventions

BIOLOGICALARCT-810

ARCT-810 is an investigational medicinal product comprising Ornithine Transcarbamylase (OTC) messenger RNA (mRNA) formulated in a lipid nanoparticle (LNP).