RecruitingPhase 4NCT04913870
Angiotensin Receptor Blockers in Aortic Stenosis
Impact of Angiotensin Receptor Blockers in Aortic Stenosis - a Randomized Controlled Trial
Sponsor
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Enrollment
144 participants
Start Date
Feb 1, 2020
Study Type
INTERVENTIONAL
Conditions
Summary
This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.
Eligibility
Min Age: 20 YearsMax Age: 99 Years
Inclusion Criteria4
- Mild to moderate aortic stenosis (peak aortic jet velocity ≥2.5 and <4m/s)
- Normal left ventricular ejection fraction (i.e. ≥50%)
- Systolic blood pressure >110 mmHg
- Diastolic blood pressure >70 mmHg
Exclusion Criteria11
- More than mild aortic or mitral regurgitation, or mitral stenosis
- Current use or documented indication for renin-angiotensin system medication or Aliskiren
- Known allergy or intolerance to angiotensin II receptor blockers (ARBs)
- Alzheimer, dementia or known non-compliant patient
- Renal dysfunction (glomerular filtration rate <30ml/min/1.73m2)
- Chronic hyperkalemia
- Diagnosed hepatic failure, cirrhosis, hepatitis or history of hepatic impairment
- Newly diagnosed (<2 months) or poorly controlled diabetes
- Pre-existing obstructive coronary artery disease with CCS III-IV angina or recent myocardial infarction (<3 months)
- Pregnant or lactating women
- Patients unable to read, understand or sign research consent
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Interventions
DRUGAngiotensin Receptor Blockers
Angiotensin Receptor Blockers treatment for 2 years.
OTHERPlacebo
Placebo administration for 2 years.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04913870
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