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RecruitingNot ApplicableNCT04934007

Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

A Randomized Control Trial of Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

Sponsor

Centre Hospitalier Henri Laborit

Enrollment

136 participants

Start Date

Sep 6, 2021

Study Type

INTERVENTIONAL

Conditions

Obsessive-Compulsive Disorder

Summary

According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

  • Age: Participants will be both males and females, 18-65 years of age included.
  • diagnosis of OCD
  • all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks
  • Affiliation to a social security system (recipient or assignee),
  • Signed written inform consent form

Exclusion Criteria6

  • In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded
  • The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0.
  • Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,
  • Patient under curators
  • Patient hospitalized under duress
  • Patient unable to give his or hers informed consent

Interventions

DEVICErTMS Treatment

1 Hz rTMS

Locations(2)

Sorbonne University, Pitié-Salpêtrière Hospital

Paris, France

Centre Hospitalier Henri Laborit

Poitiers, France

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NCT04934007

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