SEEG-Guided DBS for OCD

This study is testing a brain stimulation approach called deep brain stimulation (DBS) for people with severe, treatment-resistant obsessive-compulsive disorder (OCD). Before placing the permanent stimulator, researchers first use special brain monitoring (SEEG electrodes) to map the best location to target, with the goal of improving outcomes compared to standard DBS. **You may be eligible if...** - You are between 22 and 75 years old - You have had severe OCD for more than 5 years that significantly disrupts daily life - You have tried at least 2 different SSRI medications at adequate doses, an antipsychotic add-on, clomipramine, and cognitive behavioral therapy, without adequate relief - You live within 6 hours driving distance of the study site and plan to stay in the area for roughly 2 years - You have stable housing and at least two emergency contacts **You may NOT be eligible if...** - You have another primary psychiatric diagnosis such as bipolar disorder, schizophrenia, or an active eating disorder - You have current suicidal risk or a history of a suicide attempt - You have a pacemaker or other implanted electrical or brain device - You have metal in your head (outside the mouth) - You are pregnant or plan to become pregnant during the 3-year study - You have a history of significant head trauma or other serious medical conditions Talk to your doctor to see if this trial is right for you.