Safety of Splenic Stimulation for RA

This study is evaluating the safety of using a small electrical device to stimulate the spleen (via a nerve called the vagus nerve) as a treatment for rheumatoid arthritis (RA) — a chronic autoimmune disease causing joint pain and inflammation. This approach is called bioelectronic medicine and aims to calm the immune system without drugs. **You may be eligible if...** - You are between 22 and 75 years old - You have been diagnosed with adult-onset rheumatoid arthritis for at least 6 months - Your RA is currently active (you are still having symptoms) - You have tried at least 2 biologic drugs or JAK inhibitors for RA that did not work well enough - You are female with no childbearing potential **You may NOT be eligible if...** - You have had a previous vagotomy (surgical cutting of the vagus nerve) - You have a pacemaker, ICD, or other implanted electrical device - You have had your spleen removed - You have active or latent tuberculosis - You have HIV or active hepatitis B or C - You have uncontrolled inflammatory diseases, active serious infections, or a history of cancer in the past 5 years - You use chronic opioid pain medications (morphine or oxycodone) Talk to your doctor to see if this trial is right for you.