RecruitingNot ApplicableNCT04956549

Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)

Reducing African Americans' Alzheimer's Disease Risk Through Exercise-Mild Cognitive Impairment Cohort


Sponsor

Pennington Biomedical Research Center

Enrollment

144 participants

Start Date

Jun 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. RAATE-MCI is a 52-week randomized controlled trial. 144 African American adults aged 60 and older will be recruited.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an exercise program reduces the risk of Alzheimer's disease in African American adults who are showing early signs of memory and thinking problems (called mild cognitive impairment, or MCI). African Americans are disproportionately affected by Alzheimer's, and exercise may help protect the brain. **You may be eligible if...** - You self-identify as African American - You are 60 or older - You show signs of mild cognitive impairment (memory or thinking slightly below normal for your age and sex) - You have not been regularly exercising - You are physically capable of exercising - You plan to stay in the study area for the next 13 months - You are willing to attend group sessions **You may NOT be eligible if...** - You have significant cognitive impairment consistent with dementia - You are already very active (meeting or exceeding recommended physical activity levels) - You have uncontrolled high blood pressure (above 150/90 mmHg) - You have had a heart attack, major surgery, stroke, or fracture in the past 6 months - You have another household member already in this study - You refuse to allow your anonymized data to be used for research - You have another medical or psychiatric condition that could interfere with safe participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPhysical activity program

Supervised group sessions will be held twice per week for approximately 52 weeks. Each physical activity session will last slightly approximately 80 minutes and will consist of aerobic, strength, flexibility, and balance training. The 80 minutes of activity consists of a 5 minute warm-up, 45 minutes of aerobic training, 15 minutes of strength training, 10 minutes of balance training, and a 5 minute cool-down. The physical activity group will target 150 minutes of moderate to vigorous aerobic physical activity and two days of strength training, consistent with the current physical activity recommendations.

BEHAVIORALSuccessful Aging

The successful aging group will be based on a low-intensity activity program and a healthy aging educational component. Sessions will be approximately 60 minutes in duration and will occur once per week for the first 6 months and then every other week for the remainder 6 months of the study. The physical activities will include stretching, balance training, flexibility, relaxation, and practicing activities of daily living. The successful aging education component will cover topics including avoiding scams, fall prevention, living wills, and dementia awareness.


Locations(1)

Pennington Biomedical Research

Baton Rouge, Louisiana, United States

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NCT04956549


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