RecruitingPhase 4NCT04957329

Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells

Department of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 13, 2600 Glostrup, Denmark


Sponsor

Rigshospitalet, Denmark

Enrollment

28 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

a randomized, investigator-blind, interventinal study will compare the effect of benzalkonium-chloride (BAK) preserved and preservative-free (PF) eye drops on conjunctival goblet cells.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Age \>18years
  • Danish speaking
  • Open angle glaucoma or ocular hypertension
  • Average intraocular pressure equal to or above 22 mmHg

Exclusion Criteria1

  • a. history of significant eye diseae (including okular trauma) other than open angle glaucoma and ocular hypertension d. treatment with steroids within the last 3 months from inclusion e. Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, stroke, lung disease and autoimmune diseases. Diseases are not reason for exclusion if they are well treated or does not need treatment g. pregnant or breast feeding h. women using unsafe anticonception i. allergy towards trial medication j. patients who cannot cooperate in eye examination k. ocular surface defects l. need for polytherapy in glaucoma treatment

Interventions

DRUGXalatan

Eye drop

DRUGMonoprost

Eye drop


Locations(2)

Department of ophthalmology, rigshospitalet.glostrup

Glostrup Municipality, Danmark, Denmark

Department of drug design and pharmacology, University of Copenhagen

Copenhagen, Denmark

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NCT04957329


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