RecruitingPhase 4NCT04957329

Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells

Department of Ophthalmology, Rigshospitalet-Glostrup Valdemar Hansens Vej 13, 2600 Glostrup, Denmark


Sponsor

Rigshospitalet, Denmark

Enrollment

28 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

a randomized, investigator-blind, interventinal study will compare the effect of benzalkonium-chloride (BAK) preserved and preservative-free (PF) eye drops on conjunctival goblet cells.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of eye drops used to treat glaucoma (high eye pressure that can damage vision): a standard version preserved with benzalkonium chloride (a common preservative that can irritate the eye surface) versus a preservative-free version. The goal is to see whether the preservative-free version is kinder to the cells on the surface of the eye. **You may be eligible if...** - You are over 18 years old and speak Danish - You have open-angle glaucoma or high eye pressure (ocular hypertension) - Your average eye pressure is 22 mmHg or above **You may NOT be eligible if...** - You have significant eye disease other than glaucoma or high eye pressure - You have used steroids in the last 3 months - You have significant untreated health conditions (e.g., uncontrolled high blood pressure, diabetes, heart failure, autoimmune diseases) - You are pregnant or breastfeeding - You use unsafe contraception (for women of childbearing age) - You are allergic to the trial medications - You have surface defects on the eye or need more than one eye pressure-lowering medication - You cannot cooperate with eye examination Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGXalatan

Eye drop

DRUGMonoprost

Eye drop


Locations(2)

Department of ophthalmology, rigshospitalet.glostrup

Glostrup Municipality, Danmark, Denmark

Department of drug design and pharmacology, University of Copenhagen

Copenhagen, Denmark

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NCT04957329


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