Ocular Hypertension Clinical Trials

36 recruitingLast updated: June 18, 2026

There are 36 actively recruiting ocular hypertension clinical trials across 55 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2. Top locations include Newport Beach, California, United States, Houston, Texas, United States, Nashville, Tennessee, United States. Updated daily from ClinicalTrials.gov.


Ocular Hypertension Trials at a Glance

36 actively recruiting trials for ocular hypertension are listed on ClinicalTrialsFinder across 6 cities in 55 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Newport Beach, Houston, and Nashville. Lead sponsors running ocular hypertension studies include Glaukos Corporation, Amneal Pharmaceuticals, LLC, and PolyActiva Pty Ltd.

Browse ocular hypertension trials by phase

Treatments under study

About Ocular Hypertension Clinical Trials

Looking for clinical trials for Ocular Hypertension? There are currently 26 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ocular Hypertension trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ocular Hypertension clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 36 trials

Recruiting
Phase 4

Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension

GlaucomaOcular Hypertension
Indiana University50 enrolled1 locationNCT07588152
Recruiting
Not Applicable

Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

Open-angle Glaucoma (OAG)Ocular Hypertension (OHT)
Medical University of South Carolina172 enrolled1 locationNCT07408154
Recruiting
Phase 4

24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

Open Angle GlaucomaOcular Hypertension
Mayo Clinic30 enrolled1 locationNCT07325240
Recruiting
Not Applicable

Intraocular Pressure Measured by a Novel Sensing Contact Lens Versus Tonometry

GlaucomaOcular Hypertension
Sensimed AG12 enrolled1 locationNCT04024293
Recruiting

DSLT for Reducing Medication in Glaucoma

Ocular HypertensionPrimary Open Angle Glaucoma
The Eye Institute of West Florida60 enrolled1 locationNCT07390890
Recruiting
Phase 2Phase 3

Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension

OAG - Open-Angle GlaucomaOHT - Ocular Hypertension
Qlaris Bio, Inc.60 enrolled1 locationNCT07354516
Recruiting
Phase 1Phase 2

AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension

Open Angle GlaucomaOcular Hypertension
AbbVie96 enrolled49 locationsNCT04499248
Recruiting
Phase 4

Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

Open Angle GlaucomaGlaucomaOcular Hypertension+1 more
University of Miami20 enrolled1 locationNCT07217678
Recruiting

Observational Trial of the Updated Inserter for the Travoprost Intracameral Implant 75mcg

Ocular Hypertension (OH)Open-angle Glaucoma (OAG)
Glaukos Corporation30 enrolled1 locationNCT07400926
Recruiting
Phase 4

Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone

Glaucoma, Open-AngleOcular Hypertension (OHT)Phacoemulsification Cataract Surgery
Glaukos Corporation132 enrolled1 locationNCT06848946
Recruiting
Phase 3

Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Ocular HypertensionPrimary Open Angle Glaucoma (POAG)
Huons Co., Ltd.206 enrolled1 locationNCT07335211
Recruiting
Not Applicable

A Comparative Study of Intraocular Pressure Control Using Selective Laser Trabeculoplasty and Latanoprost as Initial Treatments for Primary Open Angle Glaucoma and Ocular Hypertension in Lagos State University Teaching Hospital

Primary Open Angle Glaucoma or Ocular Hypertension
Lagos State Health Service Commission138 enrolled1 locationNCT07310719
Recruiting
Not Applicable

Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers

GlaucomaOcular Hypertension
University of Alabama at Birmingham1,800 enrolled1 locationNCT06629649
Recruiting
Not Applicable

Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population

Ocular HypertensionPrimary Open Angle GlaucomaNormal Tension Glaucoma
BelkinVision45 enrolled2 locationsNCT05902871
Recruiting
Phase 3

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)

CataractGlaucomaOcular Hypertension
SpyGlass Pharma, Inc.400 enrolled1 locationNCT07218783
Recruiting
Phase 3

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)

CataractGlaucomaOcular Hypertension
SpyGlass Pharma, Inc.400 enrolled1 locationNCT07218796
Recruiting
Phase 3

Clarifying the Optimal Application of SLT Therapy Trial

Glaucoma and Ocular Hypertension
University of Pittsburgh790 enrolled29 locationsNCT04967989
Recruiting

Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on Glaucoma

GlaucomaOcular HypertensionLimbal Stem Cell Deficiency
National Taiwan University Hospital90 enrolled1 locationNCT07119580
Recruiting
Phase 1

Pregabalin (PRG) ophthalmic solutions in patients diagnosed with Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Ocular Hypertension (OHT)
Tavo Biotherapeutics32 enrolled1 locationACTRN12625000766415
Recruiting

A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma Patients

GlaucomaPrimary Open Angle GlaucomaPrimary Open Angle Glaucoma or Ocular Hypertension
Brian Shafer60 enrolled1 locationNCT07076303