Neuraxial Labor Analgesia and Offspring Neurodevelopment
Impact of Maternal Neuraxial Labor Analgesia on Offspring Neurodevelopment. A Multicenter, Prospective, Longitudinal Cohort Study
Dong-Xin Wang
5,580 participants
Oct 14, 2022
OBSERVATIONAL
Conditions
Summary
How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.
Eligibility
Inclusion Criteria3
- Primiparae between 18 and 35 years of age with term single cephalic pregnancy;
- Undergo regular prenatal examination in the study centers;
- Preparing to deliver vaginally.
Exclusion Criteria5
- History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);
- History of diseases involving the hypothalamic-pituitary-adrenal axis;
- Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.
- Presence of contraindications to vaginal delivery;
- Other reasons that are considered unsuitable for study participation.
Interventions
Epidural or combined spinal-epidural labor analgesia will be performed according to the routine practice of each study center.
Neuraxial analgesia will not be performed. Analgesics will be prescribed by the obstetricians according to routine practice.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT04964206