RecruitingNCT04964206

Neuraxial Labor Analgesia and Offspring Neurodevelopment

Impact of Maternal Neuraxial Labor Analgesia on Offspring Neurodevelopment. A Multicenter, Prospective, Longitudinal Cohort Study


Sponsor

Dong-Xin Wang

Enrollment

5,580 participants

Start Date

Oct 14, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study is following children born to mothers who did or did not use epidural pain relief during labour, to see whether this type of pain management affects the child's brain development in the years after birth. **You may be eligible if...** - You are a first-time mother between 18 and 35 years old - You are carrying a single baby at full term (head-down position) - You are planning to deliver vaginally - You receive regular prenatal care at one of the study centers **You may NOT be eligible if...** - You have a history of psychiatric illness diagnosed before or during pregnancy - You have a condition affecting the pituitary gland or adrenal glands - You have a medical reason that makes epidural anaesthesia unsafe (such as a history of spinal infection, spinal disease, systemic infection, or skin infection at the injection site) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURENeuraxial labor analgesia

Epidural or combined spinal-epidural labor analgesia will be performed according to the routine practice of each study center.

PROCEDURENo neuraxial labor analgesia

Neuraxial analgesia will not be performed. Analgesics will be prescribed by the obstetricians according to routine practice.


Locations(2)

Peking University First Hospital

Beijing, Beijing Municipality, China

Shenzhen Maternity and Child Healthcare Hospital

Shenzhen, Guangdong, China

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NCT04964206


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