Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

Exclusion Criteria28

• Patient going under general anesthesia for cesarean delivery
• Allergy to study medication (ketamine)
• ASA PS 4 +
• Contraindications to neuraxial anesthesia
• Preterm delivery (\<37 weeks gestation)
• Anticipated fetal-neonatal complex care plan as indicated in the patient's chart
• Patient history of ketamine or PCP abuse
• Patient history of schizophrenia or psychosis
• Patient history of liver or renal insufficiency
• Patient history of uncontrolled hypertension, chest pain, arrhythmia, head trauma, or intracranial hypertension, uncontrolled hyperthyroidism, or other contraindications to ketamine
• Participating in another pain or depression intervention trial
• Undergoing hormonal or gender affirming therapies
• Pre-eclampsia with severe features
• Hemodynamic instability
• Inability to participate in study procedures for any reason
• Control Participants
• Allergy to study medication (ketamine)
• ASA PS 4 +
• Inability to participate in study procedures for any reason
• Patient history of ketamine or PCP abuse
• Patient history of schizophrenia or psychosis
• Patient history of liver or renal insufficiency
• Patient history of uncontrolled hypertension, chest pain, arrhythmia, head trauma, intracranial hypertension, uncontrolled hyperthyroidism, or other contraindications to ketamine
• Participating in another pain or depression intervention trial
• Hemodynamic instability
• Pregnant or pregnant within the last 6 weeks
• Unwilling to provide urine sample for pregnancy testing (female controls)
• Undergoing hormonal or gender affirming therapies