Postpartum Depression Clinical Trials

44 recruitingLast updated: June 18, 2026

There are 44 actively recruiting postpartum depression clinical trials across 15 countries. Studies span Not Applicable, Phase 1, Phase 4, Phase 2. Top locations include New York, New York, United States, Taipei, Taiwan, Charlottesville, Virginia, United States. Updated daily from ClinicalTrials.gov.


Postpartum Depression Trials at a Glance

44 actively recruiting trials for postpartum depression are listed on ClinicalTrialsFinder across 6 cities in 15 countries. The largest study group is Not Applicable with 32 trials, with the heaviest enrollment activity in New York, Taipei, and Charlottesville. Lead sponsors running postpartum depression studies include National Taiwan University Hospital, The Hong Kong Polytechnic University, and University of Virginia.

Browse postpartum depression trials by phase

Treatments under study

About Postpartum Depression Clinical Trials

Looking for clinical trials for Postpartum Depression? There are currently 34 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postpartum Depression trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postpartum Depression clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 44 trials

Recruiting
Not Applicable

NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)

Self EfficacyPostpartum Depression (PPD)Engagement, Patient+3 more
Vanderbilt University Medical Center150 enrolled1 locationNCT07214597
Recruiting
Phase 4

Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression

Postpartum Depression (PPD)
Assistance Publique - Hôpitaux de Paris2,860 enrolled1 locationNCT06833788
Recruiting
Not Applicable

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention

Postpartum Depression
Michigan State University2,320 enrolled1 locationNCT05700760
Recruiting
Not Applicable

SAINT in Postpartum Depression (PPD)

Postpartum Depression (PPD)
Magnus Medical192 enrolled4 locationsNCT07210255
Recruiting
Not Applicable

The Mom and Infant Outcomes (MOMI) Study

Cardiometabolic SyndromePostpartum DepressionPostpartum Anxiety
Ohio State University384 enrolled1 locationNCT06277661
Recruiting

Maternal Expectations on Labor Analgesia and Risk of Postpartum Depression: An Observational Study

Postpartum Depression (PPD)Labor AnalgesiaExpectations
University of Padova3,640 enrolled1 locationNCT07292649
Recruiting
Not Applicable

Admission to Kangaroo Mother Care (KMC) Ward and Maternal Postpartum Depression

Low Birth WeightPre-TermPostpartum Depression+2 more
University of Alabama at Birmingham1,908 enrolled1 locationNCT06545760
Recruiting
Not Applicable

Preventing Postpartum Depression in Immigrant Latinas

Postpartum Depression
Northwestern University300 enrolled1 locationNCT05873569
Recruiting
Not Applicable

Essential Coaching Postpartum: Evaluating a Parent-focused Postpartum Text Message Program in Nova Scotia

Postpartum StressMental HealthPostpartum Anxiety+3 more
IWK Health Centre332 enrolled1 locationNCT06996067
Recruiting
Phase 1

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

PainPostpartum Depression
Grace Lim, MD, MS50 enrolled2 locationsNCT06767566
Recruiting
Not Applicable

Gestational Diabetes and Perinatal Depression: an Intervention Program

Perinatal DepressionGestational Diabetes MellitusPostpartum Depression
National Taiwan University Hospital600 enrolled1 locationNCT05800509
Recruiting
Not Applicable

Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health

InsomniaStressPostpartum Depression
University of Rome G. Marconi114 enrolled2 locationsNCT06379074
Recruiting

A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone

Postpartum Depression
Biogen200 enrolled1 locationNCT07398469
Recruiting
Not Applicable

Evaluating the Effectiveness of an Internet-based Therapy (iCARE) to Treat Symptoms of Postpartum Depression

Postpartum Depression (PPD)
University of Southern Denmark352 enrolled1 locationNCT07384273
Recruiting

A Mobile Application for Early Detection and Symptoms Trajectories of Postpartum Depression Using Ecological Momentary Assessment (EMA)

Postpartum Depression (PPD)
The Hong Kong Polytechnic University120 enrolled1 locationNCT07382336
Recruiting
Not Applicable

Narrative Nursing for Cesarean Mothers' Anxiety and Breastfeeding Confidence

Postpartum AnxietyPostpartum Depression (PPD)Breastfeeding Self-Efficacy+1 more
Xi Huang160 enrolled1 locationNCT07272252
Recruiting

Clinical Validation of a Predictive Test for Postpartum Depression

PregnancyPostpartum Depression (PPD)
University of Virginia500 enrolled2 locationsNCT06831968
Recruiting

A Study of a Test for Postpartum Depression at Home

PregnancyPostpartum Depression (PPD)
University of Virginia1,000 enrolled1 locationNCT07186309
Recruiting
Not Applicable

Understanding the Role of Doulas in Supporting People With PMADs

PregnancyDepressionSelf Efficacy+7 more
University of Montana75 enrolled1 locationNCT05763537
Recruiting
Not Applicable

Postpartum Care in the NICU (PeliCaN) Transitions

Stress Disorders, Post-TraumaticPremature BirthPostpartum Depression+1 more
University of Pennsylvania20 enrolled1 locationNCT06521398