RecruitingNot ApplicableNCT04970888

Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure


Sponsor

Montreal Heart Institute

Enrollment

216 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF). Also, the role of sex on the effects of the interventions will be assessed.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing whether combining brain training (cognitive exercises) with physical exercise is more effective than either exercise type alone for improving memory, thinking, and blood flow to the brain in people with stable chronic heart failure. **You may be eligible if...** - You are 50 years or older - You have stable chronic heart failure and have been on maximum tolerated treatment for at least 2 months - Your heart failure symptoms range from mild (class I) to significant but manageable (class III), regardless of your heart's pumping function - You are physically and mentally able to participate in both cognitive and physical training programs **You may NOT be eligible if...** - You had an acute cardiovascular event (heart attack, stroke, or hospitalisation for heart failure worsening) in the past month - You have a planned heart surgery or device implantation in the next 6 months - You are unable to perform the cognitive or physical exercise components Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCognitive training

The cognitive training will involve attention control training and memory training, with thrice-weekly 30-min sessions. Two of these sessions will involve computer or tablet-based attentional control training targeting dual-tasking, updating and working memory, as well as inhibition and switching. Difficulty of cognitive training will be tailored to participants' performances. The remaining session will consist of memory training. Participants will be instructed mnemotechnic, as well as be taught about memory in aging in general.

OTHERExercise training

Participants will follow a 20-week physical training program, with 60-min thrice-weekly trainings. The training sessions will start with a 5-min warm-up, followed by an aerobic training (20 min) after which 20-min of resistance/muscular training will take place. The program will end with a 10-min cool-down. Training will be adapted to individuals' baseline capacity as measured by the baseline cardiorespiratory test. For home-training sessions, participants will have access to a complete exercise training program. A certified kinesiologist will supervise trainings. With the Heart rate sensor Polar H10, all the characteristics of the activities will be recorded (type of the activity, intensity, heart rate, duration). A kinesiologist will call participants every week to ensure the smooth running of the exercises training sessions and individualize the care according to the patient's level.

OTHERUsual care

All patients will receive usual care and be treated according to evidence-based treatments. This will include optimal medical therapy, systematic information regarding dietary and fluid management, and a recommendation for regular physical activity consistent with the latest update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure. Moreover, patients who benefit from a prescription for a cardiovascular rehabilitation program will be able to follow it, but they will not receive other forms of intervention for the duration of the study.


Locations(1)

Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute

Montreal, Quebec, Canada

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NCT04970888


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