Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer

This study is testing whether adding preventive radiation to the lymph nodes around the aorta (the major abdominal artery) reduces the risk of cancer spreading there in women with locally advanced cervical cancer who have positive pelvic lymph nodes but no spread to the para-aortic area. **You may be eligible if...** - You are a woman between 18 and 75 years old - You have cervical cancer (squamous cell, adenocarcinoma, or adenosquamous type) - Your cancer is stage IB2–IVA with positive pelvic lymph nodes and no para-aortic lymph node involvement (confirmed by PET-CT) - You are medically fit to receive cisplatin chemotherapy - You have a good performance status (ECOG 0–1) and expected survival over 6 months - Pregnancy test is negative if you are of childbearing age **You may NOT be eligible if...** - Cancer has already spread to the para-aortic or common iliac lymph nodes - You cannot tolerate cisplatin chemotherapy - You have stage IVB (distant metastatic) cervical cancer - You are pregnant Talk to your doctor to see if this trial is right for you.