RecruitingNCT04993859

Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children


Sponsor

University of Colorado, Denver

Enrollment

152 participants

Start Date

Jun 2, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.


Eligibility

Min Age: 5 YearsMax Age: 13 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether specific chemotherapy drugs (vincristine and/or doxorubicin) given during childhood cancer treatment cause long-term bladder and bowel problems. It measures urinary biomarkers and non-invasive bladder tests in children who finished chemotherapy at least a year ago. **You may be eligible if...** - You are a child aged 5–13 years old - You have a history of cancer - You were treated with vincristine and/or doxorubicin as part of your chemotherapy - You finished chemotherapy at least one year before enrolling **You may NOT be eligible if...** - You had a tumor in the pelvis - You received radiation to the pelvis - You had pre-existing bladder or bowel problems before cancer treatment - You have a spinal defect or neurological disorder - You had a brain tumor or brain metastases - Your chemotherapy included cyclophosphamide or ifosfamide Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTNon-invasive Urodynamic Test (niUDS)

A noninvasive urodynamics is a simple test used to evaluate urinary flow.

DIAGNOSTIC_TESTUrinary proteomic screen

Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.

OTHERDysfunctional Voiding Symptom Score Survey (DVSS)

The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.


Locations(1)

Children's Hospital Colorado

Aurora, Colorado, United States

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NCT04993859


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