Imaging CRF X NOP Interactions in CUD

Inclusion Criteria14

• Cocaine use disorders (CUD)
• Males or females between 18 and 55 years old
• Fulfil DSM-5 criteria for cocaine use disorder
• No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
• No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, MDMA, etc., as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
• Not currently on prescription medical or psychotropic medications
• No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
• Not currently pregnant or breastfeeding
• No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
• No metallic objects in the body that are contraindicated for MRI
• Healthy Controls (HC)
• Males or females between 18 and 55 years old
• No present or past DSM-5 disorders (other than nicotine dependence)
• Criteria 5 to 9 as listed previously.