RecruitingEarly Phase 1NCT05008146

Imaging CRF X NOP Interactions in CUD

Imaging Corticotrophin-releasing Factor (CRF) X Nociceptive Opioid Peptide (NOP) Interactions in Cocaine Use Disorders (Aim 1)

Sponsor

Rajesh Narendran

Enrollment

80 participants

Start Date

Dec 31, 2020

Study Type

INTERVENTIONAL

Conditions

Cocaine Use Disorder

Summary

This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Baseline [C-11]NOP-1A PET Scan, a drug called Hydrocortisone, and others for people with cocaine use disorder. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 55 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONBaseline [C-11]NOP-1A PET Scan

Radiotracer

DRUGHydrocortisone

Intravenous, 1mg/Kg

RADIATIONPost-hydrocortisone [C-11]NOP-1A PET Scan

Radiotracer

Locations(1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

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NCT05008146

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