RecruitingEarly Phase 1NCT05011760

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

[C-11]NPA PET-amphetamine in Cocaine Use Disorders (Aim 2)

Sponsor

Rajesh Narendran

Enrollment

30 participants

Start Date

Jan 31, 2021

Study Type

INTERVENTIONAL

Conditions

Cocaine Use Disorder

Summary

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria13

Males or females between 18 and 55 years old
Fulfil DSM-5 criteria for cocaine use disorder
No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, and MDMA as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
Not currently on prescription medical or psychotropic medications
No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
Not currently pregnant or breastfeeding
No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
No metallic objects in the body that are contraindicated for MRI
No baseline BP ≥ 140/90 and/or HR ≥ 100.
No first-degree relative with an MI or stroke prior to middle age
No first-degree relative with psychosis or mania.
Completed a baseline \[11C\]NOP-1A PET scan in Aim 1 (Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)