NTS-WBRT in Brain Metastases

This study tests a type of whole-brain radiation therapy called neuroprotective hippocampal-sparing WBRT (NTS-WBRT), which is designed to protect the brain's memory center while treating cancer that has spread to the brain. The goal is to preserve memory and thinking skills compared to standard whole-brain radiation. **You may be eligible if...** - You are 18 or older - You have a solid tumor that has spread to the brain (brain metastases) and your doctor recommends whole-brain radiation - Your overall health and function meet certain minimum requirements (Karnofsky score of 70 or above) - You may have had prior brain surgery or focused brain radiation (stereotactic radiosurgery), which is allowed **You may NOT be eligible if...** - Your brain tumor is a primary brain tumor (not a metastasis from another cancer) - You cannot safely receive radiation therapy - Your health status is too poor to tolerate the treatment - Radiation would need to overlap with previously treated brain areas in ways that are not safe Talk to your doctor to see if this trial is right for you.