MeDex: No Perioperative Dexamethasone in Brain Metastases

This study is testing whether brain tumor surgery can be done safely without using steroid medication (dexamethasone) before and after the operation. Doctors routinely give steroids to reduce brain swelling, but steroids have side effects — this trial wants to find out if skipping them is just as safe. **You may be eligible if...** - You are 18 or older - You have a brain tumor on imaging that is suspected or confirmed to be a metastasis (cancer that spread from elsewhere in the body) - You are able to move around on your own more than half the day - Your brain scan shows minimal shifting of brain structures (midline shift ≤10 mm) - Surgery is planned to remove most of the tumor - You have not used steroids recently **You may NOT be eligible if...** - You have additional untreatable brain metastases larger than 2 cm - You have small cell lung cancer - You have been on steroids or need them for another condition - You have severe kidney disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.