RecruitingNCT05014178

Kidney Sodium Functional Imaging

Kidney Sodium Functional Imaging: Evaluation of Kidney Medullary Sodium Content Using 23Na MRI in Kidney Disease

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Enrollment

200 participants

Start Date

Sep 16, 2021

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Disease ADPKD Nephrolithiasis

Summary

The corticomedullary gradient is largely responsible for developing the gradients that are needed to concentrate urine (more solutes and less water). The ability of the kidneys to produce concentrated urine is a major determinant of the ability to survive the warm weather. When temperatures are high, we lose water through sweat, and so the kidneys retain water to maintain fluidity in the blood. The maintenance of a sodium (salt) gradient is required for urine concentration because increased medullary sodium concentration increases the reabsorption of water into the kidney, to be redistributed in the blood. The purpose of this study is to know if the corticomedullary gradient is altered in patients across a wide spectrum of kidney disease using sodium Magnetic Resonance Imaging (MRI), a machine that takes pictures and measures the salt content in the kidneys. 23Na kidney MRI, will provide functional MR of the kidney as a non-invasive tool to describe medullary function to improve management of chronic and kidney disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of MRI (sodium MRI) to look at how kidneys handle sodium. Researchers want to understand kidney function better in healthy people, people with chronic kidney disease, and people on dialysis. **You may be eligible if...** - You are 18 or older - Healthy controls: You have no kidney disease, heart failure, liver cirrhosis, or swelling from fluid - Chronic kidney disease group: Your kidney function (estimated GFR) is below 90 mL/min/1.73m² - Dialysis group: You have been on hemodialysis or peritoneal dialysis for more than 3 months **You may NOT be eligible if...** - You are pregnant, breastfeeding, or trying to become pregnant - You cannot have an MRI (due to a pacemaker, metal implants, a pump, or claustrophobia that cannot be managed) - You have a body size that makes MRI scanning not feasible Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSodium-23 MRI

Participants will lay in the MRI bed for approximately 60 minutes during scanning while the MRI technologist takes detailed pictures of their kidneys.