Nephrolithiasis Clinical Trials

27 recruitingLast updated: June 18, 2026

There are 27 actively recruiting nephrolithiasis clinical trials across 13 countries. Studies span Not Applicable, Phase 4, Phase 2. Top locations include Chicago, Illinois, United States, Birmingham, Alabama, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Nephrolithiasis Trials at a Glance

27 actively recruiting trials for nephrolithiasis are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Chicago, Birmingham, and Dallas. Lead sponsors running nephrolithiasis studies include University of Kansas Medical Center, University of Alabama at Birmingham, and Northwestern University.

Browse nephrolithiasis trials by phase

Treatments under study

About Nephrolithiasis Clinical Trials

Looking for clinical trials for Nephrolithiasis? There are currently 28 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Nephrolithiasis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Nephrolithiasis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting
Not Applicable

O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease

NephrolithiasisKidney StoneUrolithiasis+5 more
University of Alabama at Birmingham40 enrolled2 locationsNCT06330246
Recruiting
Not Applicable

Gut Oxalate Absorption in Calcium Oxalate Stone Disease

HealthyNephrolithiasisKidney Stone+6 more
University of Alabama at Birmingham80 enrolled2 locationsNCT06331546
Recruiting
Not Applicable

Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease

HealthyHealthy VolunteerKidney Stones+6 more
University of Alabama at Birmingham80 enrolled2 locationsNCT06989320
Recruiting
Not Applicable

HoYAG vs TFL in miniPCNL With ClearPetra

NephrolithiasisKidney Stone
University of Kansas Medical Center150 enrolled1 locationNCT07087977
Recruiting
Not Applicable

Evaluation of the LithoVue Elite Ureteroscope With Intra-Renal Pressure Monitoring Technology: Examination of Surgeon Behavior and Post-operative Outcomes

NephrolithiasisKidney Stone
University of Kansas Medical Center80 enrolled1 locationNCT06576661
Recruiting
Not Applicable

Comparing Efficiency and Stone-Free Rates Mini PCNL vs Flex URS

Kidney StonesNephrolithiasisUrolithiasis
Northwestern University80 enrolled1 locationNCT07072598
Recruiting
Not Applicable

Effect of Comprehensive Spa Care on Kidney and Urological Conditions: A Clinical Study in Adult Patients

Kidney DiseasesUrologic DiseasesUrinary Tract Infections+3 more
Institute of Spa and Balneology, public research institution150 enrolled1 locationNCT07435844
Recruiting
Not Applicable

Effect of Complete Suction-Induced Collapse of the Renal Collecting System at the End of RIRS on Early Postoperative Outcomes

Kidney StonesNephrolithiasisRenal calculi
Kangdong Sacred Heart Hospital90 enrolled1 locationNCT07535281
Recruiting
Not Applicable

Early vs Delayed Extracorporeal Shock Wave Lithotripsy for Residual Stones After Percutaneous Nephrolithotomy

Nephrolithiasis
Beni-Suef University476 enrolled1 locationNCT07523074
Recruiting
Not Applicable

Comparison Between Different Types of Flexible Ureteroscopes

NephrolithiasisRenal calculi
Ain Shams University180 enrolled1 locationNCT07360353
Recruiting
Not Applicable

ClearPetra™ Vacuum-assisted Ureteral Access Sheath vs Traditional Approach

NephrolithiasisKidney Stone
University of Kansas Medical Center150 enrolled1 locationNCT06547632
Recruiting
Not Applicable

Comparison of Extracorporeal Shock Wave Lithotripsy Versus Retrograde Intrarenal Surgery in the Management of Renal Calculi

NephrolithiasisRenal calculi
Ziauddin Hospital98 enrolled1 locationNCT07261995
Recruiting
Phase 2

Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

Nephrolithiasis
University of Chicago116 enrolled1 locationNCT06635889
Recruiting
Not Applicable

Comparison Between Ureterorenoscopy With Lithotripsy Alone Versus Combination With Hydrogel for Kidney Stone Removal

UreteroscopyNephrolithiasisLithotripsy, Laser
Technical University of Munich120 enrolled1 locationNCT06469736
Recruiting

Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.

NephrolithiasisUrosepsis
University of Miami150 enrolled1 locationNCT04669886
Recruiting
Not Applicable

Hemodynamic Effects of Surgical Position in Prone vs. Supine Percutaneous Nephrolithotomy

Prone PositionNephrolithiasishemodynamic stability+3 more
Gaziosmanpasa Research and Education Hospital84 enrolled1 locationNCT07138872
Recruiting
Phase 4

Alpha-Blockers Prior to Ureteral Access Sheath Placement in Flexible Ureteroscopy: A Randomized Prospective Study

NephrolithiasisAlpha BlockerUreteral Access Sheath
Pedro de Figueiredo Buchalla140 enrolled1 locationNCT07124299
Recruiting
Not Applicable

Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)

Kidney StonesNephrolithiasis
University of California, San Diego50 enrolled1 locationNCT06721975
Recruiting
Not Applicable

Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure

Kidney DiseasesNephrolithiasisUrolithiasis+3 more
Northwestern University126 enrolled1 locationNCT05100017
Recruiting
Not Applicable

RIRS With Flex Suction Sheath vs. PCNL for 2-3 cm Renal Stones

Nephrolithiasis
Changhai Hospital308 enrolled1 locationNCT07058402