Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer

This study examines how well clinical response (how a tumor shrinks on imaging during treatment) correlates with the actual pathological response (what is found in the tumor tissue during surgery) in people with early-stage breast cancer receiving chemotherapy before surgery (neoadjuvant treatment). **You may be eligible if...** - You are 18 or older (men and women are eligible) - You have invasive breast cancer confirmed by biopsy - Your breast cancer is triple-negative, HER2-positive, or high-risk hormone receptor-positive (meeting at least 2 of these criteria: grade 3 tumor, age 50 or younger, low estrogen receptor score, or high Ki-67) - Your tumor is at least 2 cm on exam or imaging - You are scheduled to receive chemotherapy before surgery **You may NOT be eligible if...** - You have low-risk hormone receptor-positive breast cancer that does not meet high-risk criteria - You have already had surgery for this tumor - You have other serious medical conditions that could interfere with the study Talk to your doctor to see if this trial is right for you.