Renal Denervation to Treat Heart Failure With Preserved Ejection Fraction

This trial tests whether renal denervation — a catheter-based procedure that uses radiofrequency energy to reduce overactive nerve signals in the kidney — can improve symptoms in patients who have heart failure with preserved ejection fraction (HFpEF) combined with high blood pressure. HFpEF means the heart squeezes normally but is too stiff to fill properly. **You may be eligible if...** - You are 18–80 years old - You have confirmed high blood pressure managed with medications - You have HFpEF with symptoms (NYHA Class II or III — meaning some to significant limitations with activity) - Your heart fills under elevated pressure (confirmed by catheterization) - Your heart pumps at 55% or more efficiency - Your NT-proBNP (heart stress marker) is elevated **You may NOT be eligible if...** - Your kidney arteries are too small or have disease (stenosis, aneurysm, prior stent) - You have a single functioning kidney - You have severe valve disease or other structural heart conditions - You are pregnant or of childbearing potential without adequate contraception Talk to your doctor to see if this trial is right for you.