RecruitingNot ApplicableNCT05043935

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis Patients: A Randomized Controlled Clinical Trial

Sponsor

Kafrelsheikh University

Enrollment

20 participants

Start Date

Nov 22, 2021

Study Type

INTERVENTIONAL

Conditions

Photodynamic Therapy L-PRF Aggressive Periodontitis

Summary

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria4

systemically healthy
non- smoker,
not received any periodontal treatment within the last 6 months,
no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months

Exclusion Criteria6

any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,
any medical condition that required antibiotic prophylaxis before the treatment,
smoking,
pregnancy and lactation,
ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,
any physical limitations or restrictions that might preclude normal oral hygiene procedures.

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.