Photodynamic Therapy With Hydrogel Dressing for Chronic Wounds
Investigation the Clinical Effectiveness of Combination Topical Aminolaevulinic Acid-Photodynamic Therapy With Hydrogel Dressing for Treatment Chronic Cutaneous Wounds
Army Medical University, China
69 participants
Jan 1, 2023
INTERVENTIONAL
Conditions
Summary
63 patients with chronic infectious wounds were enrolled in the controlled study. They were randomly divided into three groups equally. Group 1 (Grp.1): The patients received hydrogel dressing change at three days intervals. Group 2 (Grp.2): The patients received ALA-PDT treatment at ten days intervals for 4 sessions. Groups 3 (Grp.3): The patients received ALA-PDT at ten days intervals for 4 sessions combined with hydrogel dressing change every three days intervals. The wound healing rate, total effective rate, patient satisfaction, adverse reaction, and recurrence were assessed in all groups.
Eligibility
Inclusion Criteria4
- \) patients with chronic wounds caused by trauma or surgery who failed to heal after traditional formal medical treatment at least over three months;
- \) Patients with stable vital signs who had no systemic medical disease and did not take glucocorticoids, immunosuppressive agents, or anticoagulants during the entire treatment process;
- \) Participants provided signed informed consent, were able to comply with the program, were willing to participate in follow-up, and were able to cooperate in the observation of adverse events and efficacy;
- \) The diameter of the skin wound should not exceed 10 centimeters.
Exclusion Criteria5
- \) Patients are allergic to ALA;
- \) Women with recent fertility, pregnancy or lactation plans;
- \) Patients with deepening wounds or worsening infections;
- \) Poor compliance leading to an inability to complete the treatment in its entirety;
- \) Cutaneous ulcer caused by vascular disease, autoimmune diseases, metabolic diseases, local or metastatic malignant tumors.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
A number of studies have reported that PDT can accelerate wound healing by inactivating local bacterial infection and colonization of bacterial biofilm, promoting wound re-epithelialization.
Hydrogel dressing is widely applied in clinical practice to improve the regeneration ability of wound granulation tissue, promote the division and migration of epithelial cells, speed up wound healing and relieve the pain.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06445699