A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

This study is testing whether memantine — a drug usually used for Alzheimer's disease — can help patients with liver cirrhosis and liver cancer (hepatocellular carcinoma) who are not candidates for aggressive treatment. **You may be eligible if:** - You are 18 or older - You have newly diagnosed, confirmed liver cancer that cannot be surgically removed - You have cirrhosis with a Child-Pugh score of B7 or higher (moderate liver disease) - You are not a candidate for aggressive systemic cancer treatment - Your blood counts and organ function meet the minimum requirements **You may NOT be eligible if:** - You have Child-Pugh A cirrhosis (mild liver disease — may still be eligible for more aggressive treatment) - You are pregnant or nursing - You have another life-threatening illness or active tuberculosis - You have significant heart problems - You are already enrolled in another interventional clinical trial Talk to your doctor to see if this trial is right for you.